5/18/2025
Last update
5/18/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.9
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
9
We investigated the effects of a daily dose of 300 mg vitamin E for treating metabolic dysfunction-associated steatohepatitis (MASH). In our study, 124 non-diabetic individuals were randomly assigned to either vitamin E or a placebo.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
Read More
9
We analyzed multiple clinical trials to understand how vitamin E impacts liver disease, specifically metabolic dysfunction-associated steatotic liver disease (MASLD).
Our findings reveal that vitamin E significantly improves key liver markers like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting it may help reduce liver inflammation.
Additionally, vitamin E enhances liver histology by decreasing fat accumulation and inflammation. However, it does not appear to affect liver fibrosis.
Overall, vitamin E could be a valuable option for managing liver health in MASLD patients.
Our findings reveal that vitamin E significantly improves key liver markers like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting it may help reduce liver inflammation.
Additionally, vitamin E enhances liver histology by decreasing fat accumulation and inflammation. However, it does not appear to affect liver fibrosis.
Overall, vitamin E could be a valuable option for managing liver health in MASLD patients.
Read More
Most Useful Reviews
9
Supports eye health
50 people found this helpful
I use selenium for treating endocrine ophthalmopathy, and currently, in Russia, there are no pure selenium products available. This selenium combines three forms, and I alternate it with another brand. Endocrinologists recommend its use for mild cases. After four months, I can attest to its effectiveness; my symptoms have significantly improved, including the regression of eye issues related to thyroid disease.
Read More
9
Miraculous health improvement
10 people found this helpful
This is the one to get. I'm so glad I bought this. I realised the symptoms I experienced were due to an unsupported liver that was becoming overwhelmed by daily toxins. I had a serious issue for over six months. I was advised that selenium would help support my liver and enable it to detoxify, and after two weeks of taking this, the major symptoms completely disappeared. It feels like a miracle. Many people may not experience such dramatic health improvements, and I couldn't be happier.
Read More
8
Important nutritional supplement
7 people found this helpful
I took selenium for its wonderful components and its benefits in enhancing liver function. Now, on the twenty-fifth day, I find it an important nutritional supplement with no symptoms and no taste. We take one pill a day with meals. The package lasts three months. I believe it benefits hormones in women and male fertility. I hope this information helps you. Good luck to everyone!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.9
- All Researches
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
Read More
9
Selenium enhances liver health
We set out to investigate if selenium, along with glutathione, can help reduce liver injury caused by a cancer-inducing substance in mice. Over 20 weeks, we divided male mice into different groups, some receiving selenium and others just glutathione, while monitoring their liver function.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Read More
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Read More
9
We investigated the effects of a daily dose of 300 mg vitamin E for treating metabolic dysfunction-associated steatohepatitis (MASH). In our study, 124 non-diabetic individuals were randomly assigned to either vitamin E or a placebo.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
The results showed that 29.3% of those on vitamin E had improvements in liver histology, compared to just 14.1% in the placebo group. While we saw significant benefits in liver conditions like steatosis and inflammation, 12 serious adverse events were reported, although they weren’t linked to the treatment.
Overall, our findings indicate that vitamin E may offer meaningful improvements in liver health for those with MASH.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports eye health
50 people found this helpful
I use selenium for treating endocrine ophthalmopathy, and currently, in Russia, there are no pure selenium products available. This selenium combines three forms, and I alternate it with another brand. Endocrinologists recommend its use for mild cases. After four months, I can attest to its effectiveness; my symptoms have significantly improved, including the regression of eye issues related to thyroid disease.
Read More
9
Miraculous health improvement
10 people found this helpful
This is the one to get. I'm so glad I bought this. I realised the symptoms I experienced were due to an unsupported liver that was becoming overwhelmed by daily toxins. I had a serious issue for over six months. I was advised that selenium would help support my liver and enable it to detoxify, and after two weeks of taking this, the major symptoms completely disappeared. It feels like a miracle. Many people may not experience such dramatic health improvements, and I couldn't be happier.
Read More
8
Important nutritional supplement
7 people found this helpful
I took selenium for its wonderful components and its benefits in enhancing liver function. Now, on the twenty-fifth day, I find it an important nutritional supplement with no symptoms and no taste. We take one pill a day with meals. The package lasts three months. I believe it benefits hormones in women and male fertility. I hope this information helps you. Good luck to everyone!
Read More
9
Reduces thyroid issues
3 people found this helpful
I've taken compound selenium for many years, leading to the disappearance of my thyroid nodules within a year. I've recommended it to friends, one of whom, despite having multiple intestinal polyps and an unremarkable colonoscopy, found success with it. The supplement also has protective benefits for the liver and heart. My entire family intends to continue using it.
Read More
9
Effective for thyroid
1 people found this helpful
I found selenium to be extremely effective for patients with Hashimoto's thyroid disease. It has made a noticeable difference in health.
Read More
Frequently Asked Questions
9
Miraculous health improvement
10 people found this helpful
This is the one to get. I'm so glad I bought this. I realised the symptoms I experienced were due to an unsupported liver that was becoming overwhelmed by daily toxins. I had a serious issue for over six months. I was advised that selenium would help support my liver and enable it to detoxify, and after two weeks of taking this, the major symptoms completely disappeared. It feels like a miracle. Many people may not experience such dramatic health improvements, and I couldn't be happier.
8
Important nutritional supplement
7 people found this helpful
I took selenium for its wonderful components and its benefits in enhancing liver function. Now, on the twenty-fifth day, I find it an important nutritional supplement with no symptoms and no taste. We take one pill a day with meals. The package lasts three months. I believe it benefits hormones in women and male fertility. I hope this information helps you. Good luck to everyone!
6
Essential for liver health
74 people found this helpful
Selenium is indispensable for liver health and serves as an excellent antioxidant.
9
Supports eye health
50 people found this helpful
I use selenium for treating endocrine ophthalmopathy, and currently, in Russia, there are no pure selenium products available. This selenium combines three forms, and I alternate it with another brand. Endocrinologists recommend its use for mild cases. After four months, I can attest to its effectiveness; my symptoms have significantly improved, including the regression of eye issues related to thyroid disease.
9
Reduces thyroid issues
3 people found this helpful
I've taken compound selenium for many years, leading to the disappearance of my thyroid nodules within a year. I've recommended it to friends, one of whom, despite having multiple intestinal polyps and an unremarkable colonoscopy, found success with it. The supplement also has protective benefits for the liver and heart. My entire family intends to continue using it.
9
Effective for thyroid
1 people found this helpful
I found selenium to be extremely effective for patients with Hashimoto's thyroid disease. It has made a noticeable difference in health.
6
Support for liver detox
6 people found this helpful
Vitamin E and selenium are crucial for women's health, aiding skin quality and the first phase of liver detox, while also helping eliminate heavy metals like lead and mercury. My nutritionist recommended this complex, which I take alongside other detox preparations, and I am very satisfied. Please give a thumbs up if this was helpful!
9
Effective for thyroid disorders
This complex has proven beneficial for thyroid diseases. I'm on my second jar and remain very satisfied with its composition and the manufacturer’s quality.
6
Liver detox support
2 people found this helpful
Very good complex. I'm taking it to reduce grey hair in combination with NAC for liver detox. I additionally plan to take L-methionine as well.
7.5
Liver detox support
211 people found this helpful
Excellent! Vitamin E and selenium are vital for women's health and improve skin quality while playing a crucial role in the initial phase of liver detoxification and facilitating the elimination of heavy metals like lead and mercury from the body. My nutritionist recommended this complex, and I'm using it alongside other detox preparations with great satisfaction. Always consult your doctor before starting any supplements.
7.5
Essential for detoxification
2 people found this helpful
We live in a selenium-deficient region, so we take selenium regularly. This product is excellent as it contains three forms and a synergist of assimilation – vitamin E. Selenium is essential for phase 2 of liver detoxification and critical for the thyroid gland; without it, iodine cannot be absorbed. The drug has been effective, as confirmed by ongoing analysis.
8
We investigated whether selenium-modified Bletilla striata polysaccharide (Se-BSP) could effectively reduce liver fibrosis. Our findings revealed that Se-BSP not only improved its antioxidant properties but also showed greater efficacy in alleviating liver fibrosis compared to its unmodified version at a specific concentration. This study underscores the potential of Se-BSP as a promising treatment for liver fibrosis, a condition that can lead to more severe liver diseases.
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
7
We investigated the connection between selenium levels in the blood and non-alcoholic fatty liver disease (NAFLD), a common liver issue. Analyzing data from over 7,000 participants in the NHANES survey, we found that higher selenium levels were linked to an increased prevalence of NAFLD in both genders. Interestingly, those with higher selenium levels also showed a decreased prevalence of advanced hepatic fibrosis. This suggests that while selenium might be associated with NAFLD, it may also provide some protective benefits against severe liver damage.
References
- Jiang G, Kong H, Wang Y, Wang Y, Zhou J, et al. Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide. Int J Biol Macromol. 2025;301:140234. 10.1016/j.ijbiomac.2025.140234
- Choi H, Choi J, Go Y, Chung J. Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice. Nutrients. 2025;17. 10.3390/nu17020229
- Guo W, Weng T, Song Y. Association of serum selenium with MASLD and liver fibrosis: A cross-sectional study. PLoS One. 2024;19:e0314780. 10.1371/journal.pone.0314780
- Yang Z, Lian J, Li J, Guo W, Ni L, et al. Intestinal Microbiomics and Liver Metabolomics Insights into the Ameliorative Effects of Selenium-Enriched FZU3103 on Alcohol-Induced Liver Injury in Mice. J Agric Food Chem. 2025;73:3232. 10.1021/acs.jafc.4c06072
- Shen Q, Liu Y, Li J, Zhou D. Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury. Nutrients. 2024;16. 10.3390/nu16223878
- Liu Q, Bi J, Fan G, Wu M, Qin X, et al. Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults. J Trace Elem Med Biol. 2024;86:127566. 10.1016/j.jtemb.2024.127566
- Chen X, Lin X. Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway. Poult Sci. 2025;104:104449. 10.1016/j.psj.2024.104449
- Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. 10.1016/j.jtemb.2024.127563
- Hsiao YF, Huang SC, Cheng SB, Hsu CC, Huang YC. Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities. Int J Mol Sci. 2024;25. 10.3390/ijms252111339
- Cengiz M, Gür B, Gür F, Şahintürk V, Bayrakdar A, et al. The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats. Heliyon. 2024;10:e38713. 10.1016/j.heliyon.2024.e38713
- Chen F, Li Q, Xu X, Wang F. Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis. Turk J Gastroenterol. 2024;35:778. 10.5152/tjg.2024.24159
- Abdel-Wahhab KG, Ashry M, Hassan LK, El-Azma MH, Elqattan GM, et al. Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury. Sci Rep. 2024;14:21066. 10.1038/s41598-024-70894-6
- Shao C, Luo T, Wang S, Li Z, Yu X, et al. Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro. Chemosphere. 2024;364:143004. 10.1016/j.chemosphere.2024.143004
- Liu Y, Wang R. Association between serum selenium and non-alcoholic fatty liver disease: Results from NHANES: An observational study. Medicine (Baltimore). 2024;103:e38845. 10.1097/MD.0000000000038845
- Huertas-Abril PV, Prieto-Álamo MJ, Jurado J, Pérez J, Molina-Hernández V, et al. Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. Food Chem Toxicol. 2024;191:114845. 10.1016/j.fct.2024.114845
- Hua S, Zhong W, Sha Y, Ma M, Ge S. Negative association of composite dietary antioxidant index with risk of hepatic fibrosis in individuals underwent cholecystectomy: a cross-sectional study. Sci Rep. 2025;15:9040. 10.1038/s41598-025-93782-z
- Song Y, Ni W, Zheng M, Sheng H, Wang J, et al. Vitamin E (300 mg) in the treatment of MASH: A multi-center, randomized, double-blind, placebo-controlled study. Cell Rep Med. 2025;6:101939. 10.1016/j.xcrm.2025.101939
- Palencia-Campos A, Ruiz-Cañas L, Abal-Sanisidro M, López-Gil JC, Batres-Ramos S, et al. Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis. J Nanobiotechnology. 2024;22:795. 10.1186/s12951-024-03010-5
- Dong JX, Jiang LL, Liu YP, Zheng AX. Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES. BMC Gastroenterol. 2024;24:465. 10.1186/s12876-024-03556-6
- Sahin A, Demirel-Yalciner T, Sozen E, Ozer NK. Protective effect of alpha-tocopherol on lipogenesis and oxysterol production in hypercholesterolemia-induced nonalcoholic steatohepatitis. Free Radic Res. 2024;58:630. 10.1080/10715762.2024.2421173
- Wen H, Deng H, Yang L, Li L, Lin J, et al. Vitamin E for people with non-alcoholic fatty liver disease. Cochrane Database Syst Rev. 2024;10:CD015033. 10.1002/14651858.CD015033.pub2
- Adly AAM, Ismail EAR, Ibrahim FA, Atef M, El Sayed KA, et al. A 6-month randomized controlled trial for vitamin E supplementation in pediatric patients with Gaucher disease: Effect on oxidative stress, disease severity and hepatic complications. J Inherit Metab Dis. 2025;48:e12792. 10.1002/jimd.12792
- Al-Baiaty FDR, Ishak S, Mohd Zaki F, Masra F, Abdul Aziz DA, et al. Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial. BMC Pediatr. 2024;24:529. 10.1186/s12887-024-04993-8
- Chee NM, Sinnanaidu RP, Chan WK. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis. J Gastroenterol Hepatol. 2024;39:2545. 10.1111/jgh.16723
- Li J, Yang Y, Huang J, Ye D, Sun X, et al. A Comprehensive Investigation of Dietary Micronutrient Intakes and Risk of Alcoholic Liver Disease. J Nutr. 2024;154:2909. 10.1016/j.tjnut.2024.07.012
- Wang X, Liang X, Zhang N, Wang Y, Hu M, et al. Gamma-tocotrienol Inhibits Proliferation and Growth of HSD17B4 Overexpressing HepG2 Liver Cancer Cells. Curr Cancer Drug Targets. 2025;25:170. 10.2174/0115680096319171240623091614
- Albert SG, Wood EM. FIB-4 as a screening and disease monitoring method in pre-fibrotic stages of metabolic dysfunction-associated fatty liver disease (MASLD). J Diabetes Complications. 2024;38:108777. 10.1016/j.jdiacomp.2024.108777
- Akman AU, Erisgin Z, Turedi S, Tekelioglu Y. Methotrexate-induced hepatotoxicity in rats and the therapeutic properties of vitamin E: a histopathologic and flowcytometric research. Clin Exp Hepatol. 2023;9:359. 10.5114/ceh.2023.132251
- Malandris K, Papandreou S, Vasilakou D, Kakotrichi P, Sarakapina A, et al. Efficacy of pharmacologic interventions on magnetic resonance imaging biomarkers in patients with nonalcoholic fatty liver disease: systematic review and network meta-analysis. J Gastroenterol Hepatol. 2024;39:1219. 10.1111/jgh.16559
